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DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, s, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: carbonic anhydrase inhibitors (such as acetazolamide). Other medications can affect the removal of zonisamide from your body, which may affect how zonisamide works. Examples include other medications to treat seizures (such as carbamazepine, phenobarbital, phenytoin, primidone), rifamycins (such as rifabutin), St. John's wort, among others. Your doctor may need to adjust your dose of zonisamide if you are on these medications. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.kidney disease

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