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Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein), Prevnar , is a sterile solution of saccharides of the capsular antigens of Streptococcus pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM197 protein. Each serotype is grown in soy peptone broth. The individual polysaccharides are purified through centrifugation, precipitation, ultrafiltration, and column chromatography. The polysaccharides are chemically activated to make saccharides which are directly conjugated to the protein carrier CRM197 to form the glycoconjugate. This is effected by reductive amination. CRM197 is a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197) grown in a casamino acids and yeast extract-based medium. CRM197 is purified through ultrafiltration, ammonium sulfate precipitation, and ion-exchange chromatography. The individual glycoconjugates are purified by ultrafiltration and column chromatography and are analyzed for saccharide to protein ratios, molecular size, free saccharide, and free protein.Frequency not reported: Depersonalization, confusion, stupor, impaired attention span, impaired coordination, migraine headaches, neuralgia, peripheral neuropathy, speech disorder, parosmia, vacuolar axonopathy and hypersomnolence leading to coma and deathBefore using this medication, tell your doctor or pharmacist your medical history, especially of: dementia, seizures, low white blood cell count, difficulty swallowing, heart disease (such as coronary artery disease, irregular heartbeat), diabetes (including family history), obesity.

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Medically Reviewed by a Doctor on 5/13/2015Dextrostat (dextroamphetamine)Why Diclofenac Sodium EC should not be prescribed Diclofenac Sodium EC should not be used by people in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema) Diclofenac Sodium EC should not be used if you have a history of bleeding from the stomach or intestines. Diclofenac Sodium EC should not be used if suspect or have a history of Peptic ulcer. Diclofenac Sodium EC should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, s using Diclofenac Sodium EC and inform your doctor or pharmacist immediately. Possible Diclofenac Sodium EC Side effects More common side effects of Diclofenac Sodium EC may include: abdominal pain or cramps, constipation, diarrhea, headache, indigestion, nausea Less common side effects of Diclofenac Sodium EC may include: abdominal bleeding, abdominal swelling, dizziness, fluid retention, gas, itching, peptic ulcers, rash, ringing in the ears Rare side effects of Diclofenac Sodium EC may include: anaphylaxis (severe allergic reaction), anemia, anxiety, appetite change, asthma, black stools, blood disorders, bloody diarrhea, blurred vision, changes in taste, colitis, congestive heart failure, convulsions, decrease in white blood cells, decreased urine production, depression, double vision, drowsiness, dry mouth and mucous membranes, hair loss, hearing loss, hepatitis, high blood pressure, hives, inability to sleep, inflammation of the colon, inflammation of mouth, inflammation of the pancreas, irritability, kidney failure, liver disease, low blood pressure, nosebleed, red or purple skin discoloration and itching, sensitivity to light, skin eruptions and inflammation, scaling or peeling, sores in the gullet, Stevens-Johnson syndrome (a severe form of skin eruption), swelling of eyelids, lips, and tongue, swelling of the throat due to fluid retention, vague feeling of illness, vision changes, vomiting, yellow eyes and skin

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The most common side effect with milnacipran is nausea. Taking it with food can minimize the discomfort.

Invasive fungal infections, including hislasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, and pneumocystosis. Patients with hislasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. Antigen and antibody testing for hislasmosis may be negative in some patients with active infection. Empiric anti-fungal therapy should be considered in patients at risk for invasive fungal infections who develop severe systemic illness.

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Increased nonfasting triglycerides (at least 751 mg/dL) and glucose (greater than 250 mg/dL) have been reported in up to 11% and up to 5% of patients, respectively.[Ref]Store in a cool dry place not to exceed 86° F.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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